Mauricio Pochettino's team currently sit in fifth place in the table and are still unbeaten in the league. The same can't be said in Europe however and a 2-1 defeat in France against Monaco on Tuesday has seen Spurs knocked out of the Champions League before the final group game.
The corresponding fixture last season ended in a badly tempered 2-2 draw that put an end to Spurs' title challenge and saw Leicester City crowned the champions of England. Spurs have a dismal record at Stamford Bridge and have failed to register a victory there since a late Gary Lineker goal saw them triumph 2-1 in 1990, and they will go into the game without two of their first-choice back line. Toby Alderweireld is still out with a knee injury and Danny Rose is suspended after receiving his fifth yellow card of the season in last week's late win over West Ham United.
Striker Harry Kane is likely to be Tottenham's main goal threat and the Walthamstow born striker will be looking to add to his impressive record in London Derbies.
Since making his debut for Spurs the England international has scored 18 goals in 22 games against sides from the capital, including a brace in a 5-3 victory over Chelsea at White Hart Lane in 2015.
League leaders Chelsea, who beat Everton 5-0 in their last home game will be hoping for their two star players to continue their impressive starts to the season. Spain striker Diego Costa is currently leading the scoring charts with ten strikes so far and Belgian forward Eden Hazard, who won the October player of the month award has scored five goals in his last five outings.
A win would see Chelsea maintain their place at the top of the table whilst Spurs could go level with points with second place Liverpool with a victory.